I’m interested in that feeling of relief some of us get after taking our estradiol dose. I experience it as intense relief that washes over me and bathes me in joy. My color perception dramatically improves at the same time, it’s a very sudden shift.

I seem to only experience it when my blood levels are too low and the new dose enters the blood. With Divigel it’s after 30 minutes have passed, in my case, but only if me levels are low.

Some questions I have:

  • If I don’t feel the relief, am I overdosed?
  • If I do feel the relief, am I underdosed?
  • Why do I and some feel the relief, while others have never felt it?

I don’t expect anyone to know the definitive answers, but maybe you can share your experience? I’m really interested in learning what this is all about.

  • Jorunn@piefed.blahaj.zoneEnglish
    101·
    2 days ago

    That’s likely your menstruation cycle! Trans women have observed and experienced menstruation since HRT became a thing

    We have all the parts needed to experience menstruation, just less of some of the tissues involved, so typically we experience weaker or even not noticeable periods. Some trans women do have very strong periods including period shits, cramps, and large mood swings. It’s also possible that how we take HRT affects how noticeable the period is. I’ts not well studied for obvious reasons.

    Also, all the different ways of taking HRT have different half lives which is why you feel better or worse when low. Often doctors prescribe people valerate for injections but put people on on a 7 day injection cycle when the half life is 4.5 days, and don’t give people a high enough dose for them to have comfortable levels on day 6 and 7. Ideally valerate is instead taken every 5 days to avoid a very large dose and to avoid the 2 days of being too low.

    With gel and pills the half life is very short and so you can notice the same day if you are a few hours late, but blockers will change the experience a lot ofc.