I am pretty middle of the road when it comes to blocking, I don’t block super often but do occasionally when I’m feeling it. In total over my time I’ve amassed something like 45 blocks, but looking at the list recently I realized that almost a third of those blocks are one user. I don’t like their vibe, but they are a prolific poster and account creator. The last time I counted I had twelve blocks for their accounts, but is there a way to set up a block or filter that will keep up with them making accounts with the same name on dozens of instances?

I just checked, and I’ve blocked 17 of their accounts, all under one name. I wouldn’t be surprised if they had more accounts under different names too.
I get that they don’t like the .ml admins, but they’re stealing other people’s content and spamming.