Am I the only one who read the paper? All the comments are like: it’s only mice.
They did it in 6 different breeds of knockout mice, rats, and beagles -as in the best dog model for cancer translation to humans. They are well passed the threshold needed to show strong potential in people.
Other comments: it’s new and experimental
They have been working with it for years now and have shown efficacy down to a single dose. That is what this paper is about. They had previous tests with the compound, then with decreasing doses, and now this paper will it down to a single dose.
Other comments: there is no way this is real
Of the 9 primary authors, 4 are on NIH grants. I’m taking a wild guess no one here has had to fill one of those out, but they take about a month of solid writing and submitting evidence as to why your thing should get funded due to the shortage of scientific funding, then it gets reviewed by several rounds of blinded experts in the field to evaluate if you have any merit to what you are talking about, then you have to submit regular updates to show that you aren’t just pissing away tax dollars. On top of that, this was done out of a lab at the university of Illinois urbana-champaign, meaning you also have university funds mixed in so you have them checking in on you. Then they also had a state cancer research grant, adding more oversight.
How real is it? If you read the paper you would have seen they were using human tumors grown in the mice. This is a very well established cancer testing method. The downfall in their model, as they pointed out, is using NSG and athymin mice. These are immunocompromised mice. They bring up how with the necrotic cell death in the tumor (from the drug working ironically so well and so fast) that they don’t know how human immune systems will respond to it and that is kind of their next direction of the research.
Read the full abstract, then at least read the discussion section near the end if you want to get a better understanding of what is going on. Then if you are still interested, go back up to the intro and read through from there till you can’t any more.
While I have progressive ideas and believe the Republicans rule with malace, I also strongly believe the democrats rule with incompetence.
I would love to run for president on the party of burn down the two party system and restart from there. Make politics boring again and not some partisan winner take all spectacle. We keep pushing to out ‘wing’ the ‘wing’ and it is driving us to some bad extremes.
So yes, I will vote straight ticket Democrat for 99% of the time, but I am also disgusted by the fact anyone is even allowed to do that and people have little party letters by their name. If you didn’t research your candidate to at least know their name, then you shouldn’t be voting for them.
It is mind-blowing to me that some things are not seen as human rights and are instead seen as political posturing. In Texas we had barbed wire intentionally strung up in the Rio Grande river with the intention to drownd people and it took multiple rounds of court cases to make them take it out. Somehow killing people is acceptable rather than booking, ticketing, and sending back. Politics have now taken a place above literal lives. At the same time, when I express this I have democrats immediately agreeing and adding “just let them in!” Or “just let them stay and we will figure it out” and that is where I stop them and ask, is that what I said? No. Simply that human life is worth more than politics. Again, stringing up barbed wire in a river to intentionally drown people it true malice. But saying let them all in and figure it out later is naive at best, and incompetence at its worst.