Maybe this will fix my inability to progress with the Queen of the Highway quest? I never received the follow-up call once the previous quest was completed…

It doesn’t look to be mentioned in the patch notes. Anyone here have tips? I’d rather not re-load my last save prior to this quest, I’d lose 6 hours of progress.

Ah, the old effect size vs significance issue, thanks for clarifying. I perused the link you sent, I didn’t do a deep dive. The authors could have used more precise language.

Here’s a second paper from 2017, https://eprints.gla.ac.uk/151483/1/151483.pdf , which looks at duration of breastfeeding and SIDS. Not sure if you’ve come across it, but I was surprised to see the potential protective factors don’t begin until breastfeeding has gone on for at least 2 months.

Unfortunately I think the odds that we get a randomized clinical trial looking at breast vs formula are low - I didn’t find one in my brief Google Scholar search, but I’m also not a pediatrician.

But, ultimately, the first link i provided includes breastfeeding as part of a larger suite of recommendations for co-sleeping that, if all are followed, bring the risk of SIDS down to a comparable rate with modern safe sleep recommendations.

I’ll agree that there’s a lot of conflicting information when it comes to parenting, it’s called the mommy wars for a reason. But, I’ll disagree with you that I provides pseudoscience. I’ll direct you specifically to references 11 through 13 in the link I provided. They are dated, but peer-reviewed.

I’m also confused by your link, it appears to be a meta-analysis which “found ample evidence that both breastfeeding and [pacifier] use reduced the risk of SIDS.”

Overall, I like Cribsheet’s stance again - the best baby is a fed baby, the difference between a breastfed baby and a formula-fed baby are very minor and do not result in any persistent, dramatic differences.

Surprisingly, that’s not the entire story of SIDS - but it is one of the biggest contributing factors to why co-sleeping can be unsafe. It’s also why alcohol consumption dramatically increases the dangers.

I’ll plug some work done by La Leche League, a non-profit that provides resources for breastfeeding mothers. Now, this resource is for babies who are entirely breastfed - no bottles whatsoever - so it’s not for everyone unfortunately.

Their research has shown seven factors that, if addressed, can reduce the risk of SIDS in co-sleeping arrangements to be equal to modern safe sleep arrangements. https://llli.org/news/the-safe-sleep-seven/

I would also encourage people to read Cribsheet, which provides a fantastic deep dive into the specifics of SIDS risk. Understanding more about SIDS, and learning why safe sleep guidance exist, put my mind at ease as a new parent.

That’s not quite the same thing - the 7 digit phone number has more to do with short-term memory capacity than visual perception. Miller’s Law of short-term memory is we can store 7 +/- 2 items at a time, depending how complex they are.

https://en.m.wikipedia.org/wiki/The_Magical_Number_Seven,_Plus_or_Minus_Two

PhD in neuroscience here. I didn’t specifically study musicology, but i did study the neuroscience of music.

The theory that holds the most water, in my opinion, is that music activates all the same parts of the brain as motor processing. It makes us want to move, and to make predictions about what’s coming next. People like makimg predictions. It’s also a pro-social activity that encourages bonding and communication. These are typically positive experiences.

Edit: you mentioned we like the breaking of patterns in music. Very true, we love syncopation. But we don’t tap our foot to the rhythm, we groove to the beat.

Have you tried learning Japanese / English after learning the other? I studied Japanese and learned how to pronounce the /r/ in Japanese correctly.

For some people, the difficulty is less in production, and more in interpretation for someone who is native Japanese speaking and later learned English.

Chiming in with more context, my PhD was in neuroscience and I worked in a language lab. As others have stated, there is a critical window for learning a language. The biology behind it is fascinating.

As early as about 9 months of age, your brain begins to decide what speech sounds are important to you. For example, in Japanese the difference between /r/ and /l/ sounds doesn’t matter, but in English it does. Before 9 months, most babies can tell the difference between the two sounds, but babies living in Japanese-speaking environments (without any English) LOSE this ability after 9ish months!

Language is more than just speech sounds, though. Imagine all these nuances of language - there are critical moments where your brain just decides to accept or reject them, and it’s coded somewhere in your DNA.

Great, now I have to start proof-reading any communications I get from the FDA to make sure it didn’t hallucinate a scientific article in the citations. There’s going to be so many Vegetative Microscopy proposals.

If you’re working on a budget like I was when starting out on my own, I recommend your first purchase to be a bed frame. You can use Ceaigslist / FB marketplace to find some really cheap used options. From there, you can start buying (used) furniture that matches the bed frame. Personally, I needed a nightstand immediately after the bed frame because I wanted to put my glasses somewhere.

Good point, I’m assuming all monitors are as good as mine.

Fair point, but a lot of the article talks about how many studies aren’t meeting all four pillars of clinical trial design - that’s where my issue comes in, I think reporting that X% of trials do not meet all pillars is a bad metric.

And, not all medications these days are pills or IV infusions - some medications and treatments, which are governed by the FDA, are more invasive and more complicated.

The consent process for clinical trials has a ton of guidance (ICH GCP), but the onus is on the clinical monitors and hospitals to make sure it’s done correctly. Many trials now generate supporting documentation in which hospital staff are required to describe the circumstances in which consent was acquired. If the documents are generated, then it’s auditable.

Things get a bit hairy when you look at trials in Alzheimer’s and other cognitive disorders, because the patient may not be coherent enough to withdraw from the trial. In those cases, a legal guardian is responsible for the decision.

Unfortunately, this was an issue before Trump and will continue to be one afterwards. Assuming there even is an afterwards…

The article brings up some great points, some of which that I, an industry insider, weren’t even aware of, especially the historical context surrounding the AIDS epidemic. I’ll jump into the thread to critique an issue within the article.

One of the four pillars recommended by the FDA (control groups) are great in theory but can lead to very real problems in practice, specifically within indications that have an unmet treatment need or are exceptionally rare conditions.

If you have a disease that is 99% fatal but has 0 standard of care treatment options, is it ethical to ask a participant to enroll in a clinical trial and potentially not receive the study treatment/be on placebo? Or, what if the trial involves an incredibly invasive procedure like brain surgery - is it ethical for people to do a placebo procedure? Food for thought - and an explanation for why so few trials meet all four criteria proposed by the FDA.

Happy to answer questions about the industry if anyone has them.

Probably not. To get input from the brain, you need to place a sensor near it. But this device doesn’t get inserted into the brain, it sits in the scalp.

There are plenty of non-invasive brain reading technologies though, like EEG and near-infrared spectroscopy. They’re just big and bulky with low resolution.

Edit: in the case of prosthetics, it depends on where the disconnect is. If the brain and spinal cord are intact and the issue is in the periphery, yes, you can read the signal far away from the brain (namely the spinal cord) and then work from there.

The motor cortex is located in about the same spot in everyone, to my knowledge - I don’t know of any reported exceptions. The pre-central gyrus. Within, motor neurons are organized in specific regions that control specific body parts. Again, I don’t know of any reported exceptions - my understanding is everyone’s motor cortex has the same organization. It’s known as the cortical homunculus. https://en.wikipedia.org/wiki/Cortical_homunculus#Motor_homunculus%3Fwprov=sfla1

So by reading output from a small group of neurons, yes, you could control a prosthetic limb. It’s been done a few times, actually! But, you typically need more precision than comes from an EEG electrode, so all the examples I can think of are using invasive electrodes.

In fact, the sensory system of the brain has a very similar organization - along the postcentral gyrus, and the same stereotyped organization within. If you could stimulate the correct region of the sensory cortex, you could create a prosthetic that allows you to feel.

There are some more technical limitations though - there’s different types of sensation (e.g., pain, temperature, proprioception (position in space), texture, etc.) that are controlled by different receptors in skin and have different wires connecting to the brain. You’d have to be very careful about what you stimulate. And, any implant that delivers electricity to the brain, with our current technology, has a limited lifespan due to the brain’s immune system rejecting the implant (this is the aspect I studied).

Oh, cool, more BCI. I published in this field.

My only concern is how tenable it would be to deploy a bunch of these sensors. EEGs get coverage of the entire brain (surface, not a lot of deep brain activity). Would anyone be willing to wear hundreds, if not thousands, of micro-needles in their scalp?

If it meant controlling a prosthetic, probably. But general commercial devices - probably not.

My favorite AI fact is from cancer research. The New Yorker has a great article about how an algorithm used to identify and price out pastries at a Japanese bakery found surprising success as a cancer detector. https://www.newyorker.com/tech/annals-of-technology/the-pastry-ai-that-learned-to-fight-cancer