I’m a daily driver of Bazzite and Bluefin. I felt this way initially but it’s been generally painless. I typically check flatpak -> app image -> homebrew -> distrobox when I need something. If that fails, I use rpm-ostree and reboot.
I work in development/devops/infosec by trade and to date there hasn’t been a single package or program that I needed that I couldn’t get running with minimal fuss. I’ve even run a couple of MDM packages that my work requires.
k.