This is clearly an attempt to be poetic. He provides examples of exactly what he means immediately after that sentence.

www.purelymail.com

It was a good assumption. These days most games will work flawlessly in WINE/Proton, but the same can’t be said for other Windows software, sadly.

The Affinity suite is notoriously difficult to get working properly in WINE and/or Proton

I currently run it in a Windows 10 VM using virt-manager and the virtio drivers from RedHat to enable OpenGL acceleration on a Windows guest. It is a decent experience. Would probably be much better if I passed a USB pointer directly into the VM instead of relying on virtualization.

Haven’t tried it in WINE, and probably will never bother until the Affinity team take it seriously.