In the context of trans people, anti trans rhetoric goes away beyond “unapproved” or “unpopular” though. It’s straight up non-factual pseudoscience at best. A lot of it is straight up lies and libel/slander. It does real, lasting harm. That’s not “thought crime” as you describe.

Steinmeier: “Elon is a threat to European democracy”

Elon: “No, you are!”

Here’s the richest man in the world, but he still can’t buy better comebacks.

You just know this is going to give Trump some serious death penalty envy.

Some virus

Iirc the increase in pandemics has been an expected result of global warming.

For my money, there are three existential threats to the human species. You’ve already listed two: global warming and nuclear war. IMO the third is microplastics (although PFAS could be combined with microplastics to make a category I think we could reasonably call “forever chemicals”)