So I started HRT 6 weeks and it seems like, that the amount I have to sleephas skyrocketed since then. Before it was impossible for me to sleep more than 9-10h, now if nothing wakes me up I easily sleep 11-12h. If I wake up after 9h of sleep I feel like I barely slept at all and I get quite tired over the day. I know that this is an expected side effect of HRT (or puberty in general) but I did not expect for this to happen this fast. When did you started to get so tired?


I started HRT 11 months ago, and I have now been tired for 10 months. Around month 9 I stopped making a lot of plans I would have made otherwise. I don’t go out nearly as much now, because I don’t want to risk going to all the effort of going out just to find that I’m too tired to stand.
I have hope that things will turn around, but I’ve spent a lot of time this year searching for reassurance that others struggle with this past the initial few months. There are a lot of people who quickly got over their fatigue, and report feeling “more energetic than ever before” on E, which I found disheartening as that has not been my experience at all.
Here is my analysis of my energy troughs this year.
2 – 3 months: Initial reduction in testosterone after starting estrogen. It wasn’t a smooth start either. I was using patches at the time. Convinced that my dose was insufficient on the basis of some pretty bullshit reasoning, I self prescribed a second patch. To give me energy! Then I went a little crazy, and decided that the remedy was more estrogen, so I slapped on a third patch. I was basically incapable of sleeping for longer than an hour towards the end of this period, which can be expected of a person with very high estrogen. My endocrinologist eventually saw my insanely high E, I came clean, she told me off, and now I’m a good girl who follows her medical practitioners’ advice to the letter.
5 – 6 months: With the addition of cyproterone, my testosterone nosedived. I believe cyproterone on its own, anti–androgenic effects aside, is kind of a lot for the body to adjust to as well. I was getting up at 7 and going back to bed at 11 some days.
9 – 10 months: Cyproterone stopped working, as cyproterone has been known to do, and I had to increase my dose. So basically my T rose to somewhere between female and male range, then nosedived again. A few weeks later, I was going through the same adjustment as last time, but moreso. This was the point at which I started telling people that I’m staying home for all but the most important events.
11 months: Cyproterone is out because I was getting so upset by the fatigue. Started on progesterone instead and discovered that I am not one of the people who feels happier, less anxious and more rested after sleeping. Nope, I’m an anxious, depressed megabitch on progesterone. My dreams are terrifying, I wake up crying all the time, every sound puts me on edge, and I also weirdly feel emotionally numbed like I did on SSRIs. So we’ll see where this goes, but I feel like I’ve leapt backwards in my transition with this decision, and I am still SO TIRED!
As a bonus, I was diagnosed with POTS recently, which I know I’ve had since my teens, but which only became a problem in need of a solution in the absence of testosterone. This also impacts my sleep and energy.
One positive thing I take away from this is that I must really want this. 'Cause things really suck right now, but never have I ever considered slowing or pausing my transition. A year ago I was all “but what if I’m not really trans”, and now I think I’d sooner get a mobility scooter than stop HRT.
I hope things will be different for you, but I don’t want you to be discouraged if they aren’t, and I don’t want you to feel like something is wrong with you if things still suck 11 months in.
Fwiw I’ve heard taking progesterone orally is associated with the crazy dreams and maybe other side effects. I got that symptom plus feeling pretty lightheaded for a couple hours after taking it, but since I switched to taking it rectally I don’t get either anymore. It’s supposed to work much better taken rectally too, since it bypasses the liver. The increased absorption is supported by research I’m too lazy to find right now. You can just put the regular pill up your butt.
Yeah, I’ve been obsessively reading everything I can about progesterone, and the matter of oral v rectal always comes up. I can’t deny the science, but like I say, I do what my doctor tells me. When I get my bloods done for my next appointment, she expects to see the levels resulting from 3 months of orally administered progesterone, and changing dose or ROA at this stage just makes it harder to analyse that data. Honestly I would find all of this easier to bear if I knew that it was adequately suppressing my T, and not converting into DHT, but I’m not convinced of either of these things. Anyway, just gotta make it to February, and I’ll ask for my doctor’s blessing to boof.