MIT engineers developed an implantable reservoir that can remain under the skin and be triggered to release glucagon when people with diabetes are in danger of becoming hypoglycemic.
So far the stem cell treatments have failed because the t1d patients’ immune systems tend to attack insulin producing cells. Its unfortunately not yet a viable treatment
I apologize for implying anything offensive. Would you have any favorite treatment in trials? There was one method being developed at UBC which protected the langerfield cells using an artificial barrier that seemed the most promising. All the stem cell therapies failed afaik because they did not address immunity.
It seemed to me that immunotherapy combined with stem cell therapy was the best option but my knowledge of this subject is not great
Jesus fuck im a type 1 diabetic with appointment to recieve islet transplant. There hasn’t been a single fault in all 12 transplants they’ve performed. Theyre expanding the acceptable parameters for patients because they’ve been so successful. Ever recipient in 1 month from the surgery has been able to be free from insulin injection dependency with stable blood sugars.
How do they prevent the immune system from attacking the islet cells? The researchers in another study from a company once called ViaCyte have said that the cells (which are protected by a special membrane) were still getting attacked by the immune system and they end up becoming encapsulated by fibrotic structures. They were working on improving the membrane though but I don’t know if this method is in trials right now.
Homie ima diabetic not a doctor of diabetics lol im just trying to pass on info I’ve been told in my experience applying to the clinical trial. A quick search gives more answers than I can give.
Thats encouraging to hear. Six months without rejection or encystment is good. Human trials are going to require a longer period though but the new membrane technology is looking promising. Hope this reaches patients rapidly if it works out
So far the stem cell treatments have failed because the t1d patients’ immune systems tend to attack insulin producing cells. Its unfortunately not yet a viable treatment
As a T1D, im well aware, I keep on top of those studies in the hopes that one day there is a viable option for even a partial “cure”.
There’s a bevy of things to point about why the above suggestion was silly, yours is certainly just as valid as well.
I apologize for implying anything offensive. Would you have any favorite treatment in trials? There was one method being developed at UBC which protected the langerfield cells using an artificial barrier that seemed the most promising. All the stem cell therapies failed afaik because they did not address immunity.
It seemed to me that immunotherapy combined with stem cell therapy was the best option but my knowledge of this subject is not great
Jesus fuck im a type 1 diabetic with appointment to recieve islet transplant. There hasn’t been a single fault in all 12 transplants they’ve performed. Theyre expanding the acceptable parameters for patients because they’ve been so successful. Ever recipient in 1 month from the surgery has been able to be free from insulin injection dependency with stable blood sugars.
How do they prevent the immune system from attacking the islet cells? The researchers in another study from a company once called ViaCyte have said that the cells (which are protected by a special membrane) were still getting attacked by the immune system and they end up becoming encapsulated by fibrotic structures. They were working on improving the membrane though but I don’t know if this method is in trials right now.
Homie ima diabetic not a doctor of diabetics lol im just trying to pass on info I’ve been told in my experience applying to the clinical trial. A quick search gives more answers than I can give.
https://duckduckgo.com/?q=pancreatic+stem+cell+islet+transplant+results&t=fpas&ia=web
Thats encouraging to hear. Six months without rejection or encystment is good. Human trials are going to require a longer period though but the new membrane technology is looking promising. Hope this reaches patients rapidly if it works out
https://clinicaltrials.gov/search?cond=Diabetes+Mellitus+Type+1&intr=Islet+transplant
What the fuck are you talking about. There hasn’t been a single failed islet transplant. They are 12 for 12
The previous attempts either the cells were destroyed by the immune system or they became engulfed in fibrotic tissue
Idk how recent your info is but a quick search brings up just about exclusively stories of success.
https://duckduckgo.com/?q=pancreatic+stem+cell+islet+transplant+results&t=fpas&ia=web