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Joined 1 year ago
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Cake day: May 23rd, 2024

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  • It’s possible they haven’t discovered why yet.
    So far, I’ve found two things.

    • The pyroptosis pathway triggered is the typical one (lots of Caspase-1 proteins get assembled into a giant inflammosome complex and attack Gasdermin D, which then starts poking holes in the cell membrane).
    • The EPS3.9 molecule has a high affinity for a five separate membrane lipids.

    But without any formal biochemistry training, I am missing a lot of prerequisite knowledge.

    Is that high affinity above normal? Does it need to bind all five to enter the cell, or just any of them? Are those lipids, or that combination of lipids, exclusive to tumor cells? I have no info on any of these questions.

    It’s also entirely possible that it’s attacking healthy liver cells too, just at a reduced rate due to cancer cells being resource hogs.



  • Listen mate, the fact that you’re even reading instructions at all instead of chucking the technical stuff aside, or trying to force some unlucky family member to be tech support, puts you miles above most of the people I’ve dealt with.

    I had one guy demand I physically come down to his desk for an issue that was “blocking an important report”. It was literally just Windows asking if he wanted to overwrite an old file.